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This model is intended for the quantitative assessment of the regional cerebral blood flow. The required measurements are a static PET after the injection of a H215O bolus and external blood sampling from the start of injection. An autoradiographic solution of the 1-tissue compartment model for the exchange of an inert tracer is applied. The solution is based on the convolution of the blood activity with an exponential which contains the flow and the partition coefficient in the exponent. The convolved function is integrated over the acquisition time and compared with the integrated PET value. Given a specified value for the partition coefficient, the perfusion can be estimated by a table lookup approach.