MRGlu (FDG Autorad): Quantification with one Static Scan

The MRGlu (FDG Autorad) model is intended for the quantitative assessment of the regional metabolic rate of glucose (MRGlu). The required measurements are a static PET scan between 40 and 55 min after the injection of a FDG bolus, and external blood sampling from the time of injection until the end of the PET acquisition, as well as the analysis of one blood sample for the plasma glucose concentration. The analysis is based on an autoradiographic solution of the 2-tissue compartment model. It provides an operational equation (eq. (8) in [13]) as to how calculate the metabolic rate of glucose from the blood curve, the PET value, the plasma glucose, and 5 fixed (but modifiable) parameters: the lumped constant, K₁, k_2, k₃, and k₄.