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Acquisition and Data Requirements
Image Data |
A dynamic data set acquired long enough that the equilibrium relation is approximately fulfilled. |
TAC 1 |
TAC from a receptor-rich region (such as basal ganglia for D2 receptors). |
TAC 2 |
TAC from a receptor-devoid region (such as cerebellum or frontal cortex for D2 receptors). |
Model Preprocessing
Two regional TACs (TAC1 and TAC2) are needed for Model Preprocessing.
t* |
The least squares estimation should be restricted to a range after an equilibration time. t* marks the beginning of the range used in the multi-linear regression analysis. It can be fitted based on the Max. Err. criterion. |
Max. Err. |
The maximal relative error allowed if t* is fitted. |
BPnd |
Binding potential of the receptor-rich region TAC (BPnd = k3/k4 ). |
Threshold |
Discrimination threshold for background masking. |
The result of the multi-linear fit during Model Preprocessing is shown in the Result panel for inspection. The initial points which are not taken into account (before the t* time) are set to 0.
Map Parameters
BPnd |
Binding potential BPnd = k3/k4 . |
k2' |
Clearance rate of the reference tissue. |
-Vt/(Vt'b) |
First multi-linear regression coefficient of the operational equation (Ichise Eq.2.) |
1/b |
Second multi-linear regression coefficient of the operational equation (Ichise Eq.2.) |
-Vt/(Vt'k2'b) |
Third multi-linear regression coefficient of the operational equation (Ichise Eq.2.) |