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PXMOD Implementation

Acquisition and Data Requirements

Image Data

A dynamic PET data set with an appropriate tracer.

TAC 1

TAC from a region with irreversible binding (such as caudate for FDOPA).

TAC 2

TAC from a region without irreversible binding (such as occipital or cerebellum for FDOPA).

Model Preprocessing

Two regional TACs (TAC1 and TAC2) are needed for Model Preprocessing.

PXMOD Patlak Ref Model Pre-Processing

t*

The linear regression estimation should be restricted to a range after an equilibration time. t* marks the beginning of the range used in the multi-linear regression analysis. It can be fitted based on the Max. Err. criterion.

Note that the t* is in acquisition time.

Max. Err.

Maximum relative error allowed between the linear regression and the Patlak-transformed measurements in the segment starting from t*.

Threshold

Discrimination threshold for background masking.

K

Slope of the linear regression. K=(k2*k3)/(k2+k3).

Intercept

Intercept of the linear regression.

Start

Time in the plot which corresponds to t*.

Map Parameters

PXMOD Patlak Ref Model Parameters

K

Slope of the linear regression. K=(k2*k3)/(k2+k3).

Intercept

Intercept of the linear regression.