Introduction

Swisstrace has developed a new online blood sampler, the "twilite" system. The design of the system was optimized for animal and human research using PET as well as beta-probes. The twilite has been proven to feature excellent sensitivity, linearity and signal-to-noise, even in the presence of high external radiation, resulting in whole blood radioactivity curves with high temporal resolution. An experimental setup using an arteriovenous shunt allows acquiring arterial input curves without blood loss in rodents.