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PKIN includes some additional models, which are neither explicit compartment nor reference models. They include the important linear regression methods Logan Plot and Patlak Plot, recent alternative methods for estimating the total distribution volume, as well as simple methods to quickly calculate ratios between tissue TACs and/or the plasma concentration.
Model Name |
Description |
Graphical analysis of reversible system to calculate the total distribution volume. |
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Reformulation of the Logan plot as a multilinear analysis to reduce noise-induced bias. Result is the total distribution volume. |
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Multilinear analysis derived from the two-compartment model. Results are the total as well as the specific distribution volume. |
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Graphical analysis of irreversible system. Applied to FDG studies it allows to estimate glucose turnover. |
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Bolus/Infusion |
Based on a bolus study, the bolus/infusion ratio for an equilibrium study can be estimated |
Tissue/Plasma |
Calculate the ratio of tissue binding to plasma concentration in order to get an estimate of the total DV |
Calculate the ratio of specific binding to non-specific binding. |
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Calculate the fraction of pased tracer which is accumulated in tissue |
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Calculation of the box-counting dimension of curves |