|
|
|
|
|
PKIN features a comprehensive set of compartment models as listed below. The number of tissue compartments ranges from 1 to 3. There are different variants of the same model structure, so that prior information can be entered easily, and that coupling of physiologic parameters across region is possible.
For instance, the 2-tissue compartment model has the standard parameters K1, k2, k3, k4 . An equivalent description is by the parameters K1, K1/k2, k3, k4 . The advantage is, that the K1/k2, represents the distribution volume of the non-displacement compartment in tissue (free and non-specifically bound tracer), which can often be assumed to be the same across different tissues. Therefore, K1/k2 can be included as a common parameter in a coupled fit, hereby reducing the number of fitted parameters and thus potentially improving the identifiability of all.
Model Name |
Description |
Most basic compartment model with the blood compartment and one tissue compartment. |
|
Compartment model with the blood compartment and two sequential tissue compartments. Often used for receptor studies. |
|
The 2-Tissue compartment model including the plasma glucose and the lumped constant to calculate the metabolic rate of glucose. |
|
The same model as the 2-Tissue compartment model, except that K1/k2 is used as a model parameter instead of k2. This facilitates coupled fitting. |
|
The same model as the 2-Tissue compartment model, except that K1/k2 and the specific distribution volume are used as model parameters instead of k2 and k4. This facilitates coupled fitting and the easy generation of synthetic model curves. |
|
2-Tissue Compartment model solved by the Linear Least Squares method. |
|
Non-linear 2-Tissue compartment model for receptor tracer studies taking care of the saturation of receptor sites. |
|
Most detailed compartment model which separates free tracer in tissue from non-specific binding. |
|
Specific for dynamic H215O- PET Data with implicit deconvolution of the input curve dispersion |
|
Extends the 2 tissue compartment model by an additional input of labeled metabolites from the plasma. |
|
Same model as above, with constraints usable for fixing or coupled fitting. |
|
2-compartment model for authentic ligand and metabolites, linked by a transfer constant between the tissue compartments |
|
During a single imaging study three injections are applied: hot ligand first, then cold ligand for displacement, then a mixture of cold & hot ligand. The individual receptor parameters can be estimated. |