1-Tissue Compartment Model

The 1-Tissue Compartment Model only separates tissue uptake and washout. All tracer in tissue is included in a single compartment C₁.

Differential Equation of the Mass Balance

with input curve C_p(t), tissue concentration C₁(t), uptake rate constant K₁ [ml/ccm/min] and clearance rate constant k₂ [1/min].

Operational Model Curve

with the concentration C_B(t) of tracer in whole blood, and the blood volume fraction v_B.

Parameter Fitting

The model includes the three fitable parameters vB, K1, k2. Often, vB is fixed at a physiologic value of 3-5%.