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Acquisition and Data Requirements
Image Data |
A dynamic PET data set with [11C]-MP4A. |
TAC 1 |
TAC from a cortical target region. |
TAC 2 |
A suitable reference region must be selected as TAC 2. The findings in different publications indicate that cerebellum yields more stable results than striatum, most likely due to the higher impact of motion on the signal from the small striatum than the large cerebellum. |
Model Preprocessing
Two regional TACs (TAC1 and TAC2) are needed for Model Preprocessing.
Threshold |
Discrimination threshold for background masking. |
R1 |
The delivery in the target region relative to the reference. |
k2 |
The rate of washout from brain to blood. |
k3 |
The main parameter, the rate of tracer hydrolysis by AChE. |
Map Parameters
k3 |
The main parameter, the rate of tracer hydrolysis by AChE. |
k2 |
The rate of washout from brain to blood. |
R1 |
First coefficient of multilinear regression (Nagatsuka Eq. 3), representing the relative delivery K1/K1'. |
P2 |
Second coefficient of multilinear regression (Nagatsuka Eq. 3), representing Rl*k3 |
P3 |
Third coefficient of multilinear regression (Nagatsuka Eq. 3), representing -(k2+k3) |